Altogether, these data led to the identification of two models of human pancreatic cancer responsive to TGFβ and possibly sensitive to vitamin D, but only as a consequence of the treatment with the cytokine, due to VDR induction; these models can be used to further corroborate the 1,25(OH)2D3/TGFβ interplay in tumoral cells, and we explored this aspect in further experiments. The gene discussed is VDR; the disease is familial pancreatic carcinoma.