Cocaine is a high-potencies inhibitor of DAT (pIC50SERT ≈ 6.54, pIC50NET ≈ 5.48, pIC50DAT ≈ 7.14 [47]) and it is thought that its binding to DAT causes a rapid increase in extracellular dopamine levels [48] that produce the reinforcing effects leading to cocaine abuse. The gene discussed is SLC6A3; the disease is cocaine abuse.