MYC and non-small cell lung carcinoma: Recently, Moon and colleagues reported that treatment with nobiletin increased the accumulation of intracellular Adriamycin (ADR) in the human NSCLC A549/ADR cell line by promoting treatment efficacy through a mechanism accompanied by downregulation of the expression of Akt, neuroblastoma-derived MYC (MYCN), GSK-3β, MRP1, and β-catenin [117].