MCPH1 and malignant colon neoplasm: In colon cancer cell models, knockdown of E2F1 was correlated with loss of RAD51 expression and RAD51-dependent DSB repair [57]; furthermore, E2F1 and BRIT1 (MCPH1) were shown to form a complex that activates the transcription of BRCA1, CHK1, p73 and CASP7 [58].