This wide range of pharmacological activities of minocycline seems to be of key importance in oxaliplatin-induced neuropathic pain, considering that not only inflammatory mechanisms (e.g., increased levels of prostaglandins, IL-1, IL-6, IL-8 and TNFα) resulting from alterations in gene expressions (e.g., prostaglandin H2 disomerase encoding gene) and the dysregulation of genes associated with neuronal function have been shown to be contributors to oxaliplatin-induced neuropathy and increased neuronal excitability [69]. Here, TNF is linked to neuropathy.