CD4 and neoplasm: The exhausted CD8+ T-cell phenotype has been associated with an increased risk of tumor progression [60,61], increased dysfunctional dendritic cells (DCs) [62], and elevated numbers of immune cells, namely M2-polarized macrophages, resting mast cells, resting memory CD4+ T cells, and CD4+ Foxp3+ Tregs [60,63,64,65].