To further extend our previous reports that TIPRL contributes to the TRAIL resistance of HCCs [3] and to the aggressiveness of HCCs via positive regulation of LC3 and CD133 expression [8], we examined levels of all five variables, TIPRL, LC3, CD133, CD44, and CD46, previously reported to contribute to chemo- and radio-resistance in liver cancers. The gene discussed is CD46; the disease is liver cancer.