Considering our previous reports that TIPRL contributes to liver cancer aggressiveness via the modulation of LC3 and CD133 [8], the crucial roles of TIPRL in liver disease/cancer further support the demonstration that the variables, TIPRL, LC3, CD133, and CD44, are suitable covariates for diagnostic patients with grade 1 iCCA and prognosticating with the grade 1 iCCA and the grade 1 HCCs. The gene discussed is TIPRL; the disease is cancer.