PRRT2 and hepatocellular carcinoma: Interestingly, we observed that only two different siRNAs-TIPRL transfections significantly reduced HCC and iCCA cell proliferation, cultured in an attached, and cell viability, in an Anoikis condition than the other siRNAs-transfection did (Figure 3A,B; Figures S8A,B and S9A,B).