In this study, we examined the clinical implications of the variables, TIPRL, LC3, CD133, and CD44, all of which have been reported on in terms of their roles in liver cancers and autophagy, including hepatocellular carcinomas (HCCs) and intrahepatic cholangiocarcinomas (iCCA). The gene discussed is MAP1LC3A; the disease is intrahepatic cholangiocarcinoma.