In multivariate analysis, the only feature associated with complicated pregnancies was the preconception triple positivity for aPL, both in APS and aPL carrier group (p = 0.02, OR 2.421, CI 95% 1.112–5.273 and p = 0.03, OR 5.823, CI 95% 1.120–30.277, respectively). The gene discussed is FASLG; the disease is autoimmune polyendocrinopathy.