The TIME of poor responders to anti-PD(L)1 therapy has initially been characterized into the following types on the basis of histological observations before and after treatment with an anti-PD-L1 antibody: little or no tumor-infiltrating immune cells (immunological ignorance), intra-tumoral immune cell infiltration with minimal or no PD-L1 expression (a non-functional immune response), and an excluded immune infiltrate around the outer edge of the tumor cell cluster [19]. This evidence concerns the gene CD274 and neoplasm.