In NSCLC, immune tolerance commonly results from loss-of-function JAK mutations; T cell exhaustion/apoptosis; increased expression of suppressive modulators and cytokines, such as IDO1 and TGF-β; and the suppression of normal CD8+ T cells’ interaction with tumor cells by Tregs and MDSCs [55,56,57,58,59,60,61,63,64,71,72,73,74,75,76,77,78,79,80,81]. This evidence concerns the gene CD8A and non-small cell lung carcinoma.