CD274 and neoplasm: In this system, the TIME is classified by the level of tumor PD-L1 expression and TILs: type I, PD-L1+ and TILs+; type II, PD-L1- and TILs-; type III, PD-L1+ and TILs-; type IV, PD-L1- and TILs+ (Table 1).