TGFB1 and neoplasm: This may be due to tumor-induced T cell apoptosis, T cell suppression by suppressive cytokines, such as TGFβ, or suppressive immune cells, such as Tregs or myeloid-derived suppressor cells (MDSCs), as well as altered expression of stimulatory or inhibitory immune checkpoints or modulators on T cells and other immune cells [54,55,56,57,58,59,60,61].