ALK and non-small cell lung carcinoma: Similar results were found in another study in 100 patients from Japan: 10 NSCLC had a high-TMB (>20 mutations/Mb), among whom 2 harbored a driver mutation (1 ALK rearrangement and 1 HER2 mutation), whereas 57 of the 90 specimens with low-TMB harbored an actionable oncogenic driver mutation (ALK, ROS1, or RET rearrangement or EGFR, HER2, or MET mutation) (p < 0.05) [97].