Compared with patients with the chronic articular pattern, patients with AOSD with the systemic pattern had significantly higher ferritin levels (median 1769 μg/mL, IQR 641.5–7525 μg/mL vs. median 972 μg/mL, IQR 267–2425 μg/mL, p < 0.05), significantly higher serum IL-18 levels (median 2023.5 pg/mL, IQR 389.7–8020.8 pg/mL vs. 567.6 pg/mL, IQR 242.8–1262.5 pg/mL), and significantly higher ATG16L1 expression levels (median 2.5, IQR 1.20–7.8 vs. median 0.7, IQR 0.2–1.5, p = 0.001). The gene discussed is IL18; the disease is adult-onset Still disease.