However, the occurrence of skin rash, arthritis, sore throat, lymphadenopathy, hepatosplenomegaly, leukocytosis, disease activity scores, and levels of ferritin, IL-1, IL-6, IL-17A, IL-18, TNF-α, LC3-II mRNA, or ATG16L mRNA expression was not predictive of the systemic pattern. This evidence concerns the gene ATG16L1 and Hepatosplenomegaly.