As presented in Figure 2, significantly higher serum levels of IL-1β, TNF-α, IL-6, and IL-18 were observed in patients with AOSD (median, 1.65 pg/mL, IQR 0.79–4.09 pg/mL; 183.93 pg/mL, IQR 78.06–573.84 pg/mL; 495.08 pg/mL, IQR 222.43–1138.03 pg/mL; and 1082.82 pg/mL, IQR 347.22–7173.25 pg/mL, respectively) compared with healthy controls (0.87 pg/mL, IQR 0.00–1.45 pg/mL; 43.22 pg/mL, IQR 9.70–88.99 pg/mL; 178.07 pg/mL, IQR 97.83–333.09 pg/mL; and 138.12 pg/mL, IQR 95.28–179.79 pg/mL, respectively; all p < 0.001). This evidence concerns the gene IL6 and adult-onset Still disease.