Gao et al. [125] showed that the non-steroidal anti-inflammatory drug aspirin induced the activation of AMPK, leading to the up-regulation of mTORC2-dependent phosphorylation of Akt (S473), which was prevented by knockdown of rictor in hepatoma cell line HepG2 and colon cancer cell line SW480. The gene discussed is AKT1; the disease is hepatocellular carcinoma.