ACE2 and COVID-19: A recent in vitro study that used plasma neutrophils and tracheal aspirate from COVID-19 patients demonstrated that SARS-CoV-2 induces the release of NETs, but this depended on ACE2, serine protease activity, virus replication capacity and PAD4 function [95], indicating that experimental studies with inactivated SARS-CoV-2 may not produce reliable results.