In this connection, Yan and colleagues also showed that the Wnt/β-catenin-mediated up-regulation of syncytin-1 expression contributed to the tumor necrosis factor-α (TNF-α)-enhanced fusion of human umbilical vein endothelial cells (HUVECs) and oral squamous cell carcinoma (OSCC) cells [88]. This evidence concerns the gene TNF and oral cavity squamous cell carcinoma.