PTEN and hepatocellular carcinoma: miR-93. Considering the important role of EV-derived miRNA in HCC tumorigenesis and that miR-93 increases cancer cell growth via modulating PTEN in several types of cancer [110,111], Xue and colleagues (2018) investigated the role of EV-derived miR-93 as a new diagnostic and prognostic biomarker in HCC [112].