These observations agree with a previous report showing decreases in arterial pressure and heart rate after intra-PVN prazosin micro-infusion in undernourished hypertensive rats [48] and also with the antihypertensive effect of i.c.v. α-helical CRF [57] or antalarmin, a CRF receptor antagonist [58] in different rat models of hypertension. The gene discussed is CRH; the disease is hypertensive disorder.