CRH and hypertensive disorder: Importantly, once the elevated systolic pressure in the malnourished rats was lowered close to the normal level with one of the antagonists used herein (e.g., intra-PVN microinjected prazosin), the agonist administered in the complementary nucleus (e.g., intra-LC microinjected CRF) recovered its full potential to induce hypertension and tachycardia.