Therefore, the present results support that simultaneous concurrent tonic neuronal activity in both nuclei—the PVN and LC—is required to maintain elevated scores of systolic pressure and heart rate in the prenatally malnourished animals, as any of the two antagonists (prazosin into the PVN, α-helical CRF into the LC) could independently alleviate both hypertension and tachycardia in rats with early undernutrition. The gene discussed is CRH; the disease is hypertensive disorder.