Finally, a phase III, multicenter, randomized, open-label study is evaluating the invasive disease-free survival (IDFS) of T-DXd versus T-DM1 in patients with high-risk HER2-positive BC presenting with residual invasive disease in breast or axillary lymph nodes in the post-neoadjuvant setting (DESTINY-Breast05, NCT04622319) [16,47]. This evidence concerns the gene ERBB2 and breast cancer.