We studied the effects of the selective NLRP3 inhibitor, dapansutrile (OLT1177®), on a mouse model of severe systolic heart failure in which a 9-week oral treatment period began 7 days after MI, and herein show for the first time that the chronic inhibition of NLRP3 improves cardiac contractile reserve and preserves diastolic function after the acute healing process has occurred. This evidence concerns the gene NLRP3 and systolic heart failure.