A recently developed small molecule NLRP3 inflammasome inhibitor, OLT1177®, also known as dapansutrile (3-methanesulfonyl-propionitrile), is effective in in vitro and in vivo studies, and is currently being evaluated to help treat acute gout flares, Schnitzler’s syndrome, Alzheimer’s disease, cardiovascular diseases and others [19,20,21,22]. This evidence concerns the gene NLRP3 and gout.