CASP1 and myocardial infarction: The NLRP3 (NACHT, leucine-rich repeat, and pyrin-domain containing protein 3) inflammasome is an intracellular macromolecular structure involved in sensing danger signals, activating caspase-1, and the pyroptotic release of pro-inflammatory cytokines that initiate the sterile inflammatory response to injury that has been identified as a central mechanism in both the response to damage and the healing process of acute myocardial infarction (MI) [1,2,3,4].