Although we observed that the same experimental group showing SNAI1 downregulation also exhibited a high M1-like phenotype, we were unable to establish a link between Akt/mTOR/SNAI1 and HMGB1 secretion since we found no significant difference between the extracellular HMGB1 of Akt transfected melanoma cells and that of the control (Figure S2C). Here, AKT1 is linked to melanoma.