HMGB1 and melanoma: Although we observed that the same experimental group showing SNAI1 downregulation also exhibited a high M1-like phenotype, we were unable to establish a link between Akt/mTOR/SNAI1 and HMGB1 secretion since we found no significant difference between the extracellular HMGB1 of Akt transfected melanoma cells and that of the control (Figure S2C).