MITF and pigmentary glaucoma: GPNMB also localizes to melanosomes [54,56,57], is transcriptionally regulated by the Melanocyte-Inducing Transcription Factor (MITF) [58,59,60,61] and, when mutated, can lead to hypopigmented lesions and pigmentary glaucoma in mice (Figure 2) [7,8,18,19].