With regards to renal cancers, the Cancer Genome Atlas molecular characterization of RCCs carried out a comprehensive immune signature gene profiling demonstrating that, with the exception of Th17 (mostly characterizing chRCC), IL-8 and CD56brightNK (more expressed in pRCCs) cell genes, the others were more significantly overexpressed in ccRCC than pRCC and chRCC [107]. The gene discussed is CXCL8; the disease is nonpapillary renal cell carcinoma.