The splicing process of VEGF-A pre-mRNA may alternatively generate both a pro-angiogenic and an anti-angiogenic isoform [29,31,32]; the above-mentioned authors [29,31,32,33] hypothesized that the upregulation of SRSF1 led to an angiogenic stimulation on GBM tissue, through the switch of the proangiogenic/antiangiogenic ratio of VEGF-A. This evidence concerns the gene SRSF1 and glioblastoma.