Another approach to increase drug sensitivity refers to flavonoids and their ability to inhibit cell proliferation as well as to induce apoptosis and autophagy by downregulating Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit γ (PI3Kγ), which interrupts the PI3K/AKT/mTOR/ Ribosomal Protein S6 Kinase (p70S6K)/ULK pathway in breast cancer cells [146] (Figure 4). This evidence concerns the gene AKT1 and breast cancer.