Accordingly, inhibiting autophagy via silencing MAP1LC3 or BECN1 reduced the expression of cyclin D1, integrin-β1, and phosphorylated proto-oncogene tyrosine-protein kinase (SRC), which supports the cell cycle by inducing entrance into the G1 phase, thus promoting breast cancer initiation and progression [75]. The gene discussed is BECN1; the disease is breast carcinoma.