Furthermore, transcriptomic analysis of patient-derived BCSCs showed high levels of the 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), which was paralleled by an increased metastatic potential and improved self-renewal ability of TNBC and HER2 enriched breast cancers. The gene discussed is PFKFB3; the disease is breast cancer.