BRCA2 and triple-negative breast carcinoma: Triple negative breast cancers (TNBC) are ER−/PR−/HER2− with mesenchymal, basal-like, and claudin-low characteristics often carrying mutations in the tumor suppressor BReast CAncer 1 (BRCA1) and BReast CAncer 2 (BRCA2) genes, which play an important role in DNA repair.