KCNC4 and Alzheimer disease: On the other hand, the important involvement of KV3.4 channels in the Aβ1-42 neurotoxicity is further supported by the results showing that BDS-I, a KV3.4 blocker [50], may exert a potent neuroprotective action both in AD neurons and astrocytes exposed to Aβ1-42 oligomers [36,40].