The hallmark features of DLBCL samples belonging to the EZB subtype are genetic alterations in BCL2 that lead to enhanced BCL2 expression, and mutations in genes encoding epigenetic modifiers such as KMT2D, CREBBP, or EZH2. The conditional deletion of Kmt2d mice early in the B-cell development process, combined with Bcl2 overexpression using Cγ1Cre;Kmt2dfl/fl;VavP:Bcl2 mice resulted in DLBCL lymphomagenesis [104]. Here, EZH2 is linked to diffuse large B-cell lymphoma.