DLBCL samples belonging to the BN2 subtype are characterized by the co-occurrence of BCL6 rearrangements with aberrations in NOTCH2, SPEN, BCL10, and TNFAIP3. The combination of conditional Spen and Tnfaip3 knockout or oncogenic Notch2 alleles (which are not sufficient to generate lymphomagenesis per se) with the Iμ.HA.BCL6 knock-in DLBCL mouse model, characterized by a deregulated BCL6 expression that leads to the development of human DLBCL-like lymphomas, might fit as a robust mouse model for this subtype [92,117,118,119]. This evidence concerns the gene TNFAIP3 and diffuse large B-cell lymphoma.