Consistent with this, oncogenic mutations in Ezh2, combined with Bcl2 overexpression, also gave rise to early onset DLBCL lymphomas in Cγ1Cre;VavP:Bcl2;Ezh2Y641F/N and in irradiated wild-type mice transplanted with Ezh2Y641F-transduced VavP:Bcl2-derived HPCs [105,121]. Here, BCL2 is linked to lymphoma.