BCL2 and diffuse large B-cell lymphoma: Likewise, CREBBP loss also cooperates with BCL2 overexpression in DLBCL lymphomagenesis as shown in Mb1:Cre;Eμ:Bcl2;Crebbpfl/fl mice and in an HPC transplantation model involving VavP:Bcl2-derived HPCs transduced with Crebbp- or Ep300-shRNA transplantation into irradiated mice [103,115].