IL10 and neoplasm: Figure 2 shows that glioma cell-derived TEX can convert macrophages (M0, M1 or M2) to highly suppressive tumor-associated macrophages (TAMs) which up-regulate surface expression of immunosuppressive ligands as well as release of exosomes enriched in arginase 1and IL-10. These “secondary” TAM-derived exosomes not only have the means to suppress immune cells but also actively promote glioblastoma growth by supplying arginase1 to the tumor [69].