TLR3 and Hepatic fibrosis: However, as liver fibrosis progresses to the F2-F3–F4 phases, the loss of the correlation between the expressions of TLR3 and IFNL3 with a predominance of the GGT enzyme is evident, attributed to the presence of lesions in the bile ducts [32] and positively correlated with the METAVIR score [35] in patients with HCV.