MAPK8 and chronic myelogenous leukemia, BCR-ABL1 positive: In contrast, the 6 h incubation with CML was followed by a statistically significant upregulation of MAPK8 mRNA expression (5.9-fold; p = 0.0054 vs. CTL and 6.0-fold p = 0.0060 vs. acrylamide) (Figure 6d) and of CASP3 mRNA expression (3.5-fold; p = 0.0121 vs. CTL) (Figure 6d).