MAP3K1 and chronic myelogenous leukemia, BCR-ABL1 positive: We also observed an overexpression of genes coding for MEKK1 (MAP3K1), JNK1 (MAPK8) et p38-α (MAPK14), but also for the chemokine CXCL8, whose expression is known to be activated by the JNK and p38-α pathways, after stimulation of the co-culture by CML (300 μM) for 6 h [47].