However, a 6 h incubation with CML significantly upregulated CXCL8 mRNA expression (3.6-fold; p = 0.0098 vs. CTL and 4.4-fold; p = 0.0044 vs. acrylamide) (Figure 6a). The gene discussed is CXCL8; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.