GNRH1 and hypogonadism: Hyperprolactinemia, indeed, affects the HPG axis by decreasing gonadotropin-releasing hormone (GnRH) -mediated stimulation of GnRH receptors, thus disrupting GnRH pulsatility and gonadotropin secretion, inducing a secondary hypogonadism that could explain, at least in part, the sexual symptoms [28].