Nonfunctioning adenomas often stain for gonadotropins or their subunits and occasionally for GH, ACTH, and PRL, but they do not secrete hormones in excessive amounts and are also referred as clinically silent adenomas [21]; when large tumors arise from the pituitary, however, they may cause compression on gonadotropic cells or pituitary stalk deviation, causing hypogonadism either directly or through subsequent hyperprolactinemia, respectively [22]. This evidence concerns the gene PRL and hyperprolactinemia.