Concordantly, MR analysis revealed that, as this site becomes methylated, the expression of MAST3 decreases (B = −0.2, p = 1.6 × 10−69, Figure 4B) and the risk of obesity increases (B = −0.06, p = 6.9 × 10−14, Figure 4B). The gene discussed is MAST3; the disease is obesity due to melanocortin 4 receptor deficiency.