Moreover, in adipose tissues, MO was shown to normalize increased mRNA levels of leptin and resistin, and decreased those of adiponectin, melanocortin receptor-4, and peroxisome proliferator-activated receptors α and γ; those changes could also lead to the normalization of body composition and insulin sensitivity of DM rodents [14,18,33]. The gene discussed is INS; the disease is diabetes mellitus.