For example, hepatocyte-associated p62 aggregates are found as Mallory–Denk bodies (MDBs) in steatohepatitis and as intracytoplasmic hyaline bodies (IHBs) in hepatocellular carcinomas and copper toxicosis, and in the brain as Lewy bodies in Parkinson’s disease, neurofibrillary tangles in Alzheimer’s disease, and huntingtin aggregates in Huntington’s disease [8,12,13,14,15]. The gene discussed is SQSTM1; the disease is hepatocellular carcinoma.