One can speculate that ClpP, together with mitophagy, may help cells to maintain mitochondrial functionality by repairing or resisting to the damages caused by cisplatin, therefore, targeting ClpP could represent a new mechanism to make cancer cells sensitive to cisplatin, and the expression level of ClpP in tumor tissues could represent a potential predictive biomarker in this setting. This evidence concerns the gene CLPP and neoplasm.