This increase in VEGF and bone vascular density induced by βAR stimulation was shown to promote breast cancer cell bone metastasis, as VEGF blockade or β2AR deficiency in osteoblasts specifically reduced both vascularity and the number of metastatic bone lesions formed after intracardiac injection of triple negative MDA-MB-231 breast cancer cells and ISO administration [157]. This evidence concerns the gene ADRB2 and breast carcinoma.