KRAS and colorectal carcinoma: Consequently, in human tumors, particularly CRC, the loss of tumor suppressor activity of p53 and changes in signaling pathways associated with oncogenes MYC, HIF, and KRAS, as well as PI3K/AKT/mTOR axis, are known to play a role in deregulated cellular energetics, an established hallmark of cancer [210,211,212].