HIF1A and B-cell chronic lymphocytic leukemia: In keeping with the hypothesis of a wide-ranging beneficial effect of antagonizing HIF-1α in the non-leukemic microenvironment, previous findings show that hypoxia-driven HIF-1α overexpression impairs the function of a variety of immune populations and causes hematopoietic dysfunctions in the BM of CLL patients [14,32].