The NCT02390063 study demonstrated the elicitation of T-cell responses in patients with PCa, both before RP and during active surveillance, after the administration of two replication-deficient viruses, the ChAd (chimpanzee adenovirus) and the MVA (Modified Vaccinia Ankara) targeting 5T4, an oncofetal self-antigen [65]. This evidence concerns the gene TPBG and posterior cortical atrophy.