However, insulin-treated diabetes was not identified as an independent risk factor for higher mortality in the 1st (HR 1.29; 95% CI 0.97–1.72, p = 0.084) and 3rd years (HR 1.21; 95% CI 0.98–1.49; p = 0.079) after multivariable adjustment [116]. This evidence concerns the gene INS and diabetes mellitus.