The picture is more problematic when genetic predisposition to the development of melanoma is genetically evident as in pathological conditions such as xeroderma pigmentosum (XP), congenital melanocytic nevi, familial atypical multiple moles and melanoma (FAMMM) syndrome, as well as breast cancer type 2 susceptibility protein (BRCA2) mutation [34,35]. Here, BRCA2 is linked to large congenital melanocytic nevus.