The protein SRY-related HMG-box transcription factor 10 (SOX10) involved in the determination of embryonal cell fate, represents a sensitive biomarker for melanoma and lymph nodal staining [20], whereas the preferential expressed antigen in melanoma (PRAME), p16 and phospho-histone H3 (pHH3) are utilized for specific staining panels for discrimination of uncertain lesions [21]. This evidence concerns the gene SOX10 and melanoma.