In general in melanoma, as in other solid tumors, the presence of CD14+ monocyte-myeloid derived suppressor (M-MDSC) cells, M2 tumor associated macrophages (M2-Type TAMs) and regulatory T cells in the tumor microenvironment and in blood circulation, negatively modulates the antitumor T lymphocyte activity, eventually favoring tumor growth and spreading, in turn largely reducing outcome of immunotherapy. Here, CD14 is linked to neoplasm.