Indeed, FLT3-ITD inactivation with several FLT3 inhibitors (including AC220) used at high concentration (μM range) induced a lethal mitophagy due to ceramides accumulation in the mitochondria [50], whereas their use at a lower concentration (nM range) inhibited FLT3-ITD-induced autophagy [31] (see above “Recurrent genetic AML alterations associated with autophagy” paragraph). The gene discussed is FLT3; the disease is acute myeloid leukemia.