For cell lines with a basal ratio p-Akt/total Akt equal or higher than 1 (Figure S1), as the A549 or H1975 NSCLC cell lines, respectively, neither the concentrations of F3 peptide-targeted liposomal C6-ceramide tested nor the incubation time enabled a significant downregulation of the levels of p-Akt. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.