In fact, the presence of nucleolin was verified on the cell surface of human lung cancer cell lines and in the cell membrane of human pulmonary carcinoma tissues [25], as well as on the surface of breast cancer stem cells, non-stem breast cancer cells and endothelial cells from tumor blood vessels, rendering it as an important target in cancer therapy in the context of solid tumors [20,26,27]. This evidence concerns the gene NUCLEOLIN and cancer.