Haptoglobin is one of the major serum components that accounts for 0.4–2.6% of total blood proteins, and a highly sialylated glycoprotein containing four N-glycosylation sites (Asn184, 207, 211, and 241) on β-subunit [25], whose glycosylation changes in several types of cancer, such as hepatic, prostate, ovarian, and pancreatic [26,27,28,29]. This evidence concerns the gene HP and cancer.