CHEK2 and ovarian carcinoma: Several tumor suppressor genes and oncogenes have been associated with ovarian cancers, including the p53 tumor suppressor gene, the mismatch repair (MMR) genes, and few other genes involved, along with BRCa1 and BRCA2 in the double-strand breaks repair system, such as CHEK2, RAD51, BRIP1, and PALB2.