EGFR and cancer: EGFR-NF-κB crosstalk in cancer cells has previously been identified, showing that (1) EGFR directly or indirectly activates NF-κB in human various cells, including ER-negative breast cancer cells [202,203,204,205,206,207,208,209,210], while (2) the IKK/NF-κB pathway activates EGFR signaling [211,212,213,214].