EGFR and non-small cell lung carcinoma: From the studies on NSCLC in which mechanisms of resistance to EGFRis have been extensively studied, intrinsic EGFRi resistance of TNBC may be due to (1) EGFR-activating mutations or amplification, (2) activation of bypass signaling pathways (e.g., MET amplification), or (3) activation of downstream pathways [50,76,77,100,101].