Four Notch receptors have been associated with tumor growth (Notch1, Notch2, and Notch3), CSC regulation (Notch1, Notch2, Notch4), tumor invasion and metastasis (Notch1, Notch2, Notch3, Notch4), angiogenesis (Notch3), and drug resistance (Notch1 and Notch3) [232,233]. This evidence concerns the gene NOTCH4 and neoplasm.