KDR and thyroid gland carcinoma: Vandetanib (Caprelsa®; Zactima®; ZD6474) is an orally available RTK inhibitor targeting vascular endothelial growth factor receptor 2/3 (VEGFR2/3), rearranged during transfection (RET), and EGFR, which are important targets in thyroid cancer (Table 2) [88,89].