Figure 1b shows an extended family tree of the previously described family, in that report the propositus (I3) and her brother (I4) had their first DVT episode at the age of 20 and 21 years, respectively, characterized by following mixed arterial and venous (I3) and venous (I4) relapses in the presence of the combined AT-FV Leiden defect. Here, F5 is linked to deep vein thrombosis.