NFKB1 and Sepsis: Our experimental results demonstrated that piplartine suppresses the production of proinflammatory mediators and cytokines through inhibiting MAPKs/NF-κB signaling pathway and NLRP3 inflammasome activation by LPS-activated macrophages and protects LPS-induced septic shock, suggesting that piplartine might have benefits for treating sepsis (Figure 6).