NOS3 and type 2 diabetes mellitus: Similarly, LICUS promoted angiogenesis through regulating phosphoinositide 3 kinase, serine/threonine kinase, and the endothelial nitric oxide synthase (P13K-Akt-eNOS) pathway in human umbilical vein endothelial cells and a type 2 diabetic mouse peripheral ischemia model [50].