TP53 and neuroblastoma: However, the p53MUT neuroblastoma cell line had fewer Annexin positive (mean +/− standard error) cells than the p53WT cells (Figure 1B: p53MUT median 19%, range 12–32% (right panel) vs. p53WT median 73%, range 22–91% (left panel); p < 0.01) Apoptosis was also significantly decreased in the SH-SY5Y p53 knockdown cells compared to SH-SY5Y cells with p53WT (median 30%, range 14–36% vs. 54%, range 58–77%; p < 0.05) (Figure 2C).