Likewise, m6A-methylases (writer), m6A-demethylases FTO, and ALKBH5 (eraser) have also been found to be aberrantly expressed in APL and LSCs/LICs and promote leukemogenesis by targeting ASB2, RARA, LILRB4, CEBPA, TACC3, Myc, and the P-21 gene [51]. This evidence concerns the gene FTO and acute promyelocytic leukemia.