METTL3 and acute myeloid leukemia: Among these, the m6A-writer proteins Mettl3 and Mettl14 have been found to be aberrantly expressed in specific subtypes of AML and promotes leukemogenesis by regulating MYB, MYC, Bcl2, pTEN, and PI3K-AKT pathways [43,44,49,118].