To validate the requirement of ALKBH5 in the promotion/transformation of AML cells, Krivtsov et al., 2006 used MLL-AF9 (MA9)-induced leukemogenesis model (where MLL-rearranged fusion protein alone is sufficient to transform normal HSPCs into leukemic cells coupled with ALKBH5 knockout (ALKBH5KO) model [91]. The gene discussed is ALKBH5; the disease is acute myeloid leukemia.