They have showed that selective depletion of CISH in NK cells (CISH−/−) derived from human iPSC (induced pluripotent stem cells) significantly enhance the expansion as well as survival in the tumour microenvironment, confirmed by improved metabolic fitness of NK-cells, characterised by increased glycolytic capacity and mitochondrial respiration (OxPhos activity) via mTOR signalling response. The gene discussed is CISH; the disease is neoplasm.