In prostate cancer, overexpression of CTH increased H2S production leads to the activation of nuclear factor-κB (NF-κB)-mediated interleukin 1β (IL-1β) signaling, resulting in the enhanced cell invasion, angiogenesis, lymphangiogenesis, tumor growth, and metastasis in prostate cancer [45]. This evidence concerns the gene NFKB1 and Familial prostate cancer.